eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
185
208
10.21608/ejom.2007.625
625
OCCUPATIONAL VIOLENCE AGAINST SECONDARY SCHOOLS' TEACHERS IN ISMAILIA CITY
Waheed A.
1
Youssef I.
2
Departments of Puplic Health, Community Medicine,Occupational and Environmental Medicine, and* Psychiatry,Faculty of Medicine, Suez Canal University
Departments of Puplic Health, Community Medicine,Occupational and Environmental Medicine, and* Psychiatry,Faculty of Medicine, Suez Canal University
Background and Aim of the Work. Violence at work has been identified as a serious problem in many countries all over the world. Violence against teachers has become a silent epidemic in education. Violence can lead to serious adverse health effects.It would be quite impossible for teachers to concentrate in their learning environment if they were suffering from any physical or psychological problems. This work was aimed at determining the prevalence, nature and consequences of physical and non-physical violence against secondary schools' teachers in Ismailia city, and investigatingthe potential associations between each form of violence and several teacher-related characteristics.Subjects and Methods. This cross sectional study was conducted at secondary schools in Ismailia city, including general, technical, agricultural, industrial, and commercial schools. Eligible teachers were those working for more than one year, and notsuffering from any neurological or psychiatric problems. The participant teachers were 1036. A self-administered anonymous questionnaire was used to assess violence against teachers. It covers questions concerning socio-demographic data, job related data and violence incidents; their characteristics, perpetrators, and associated factors.IntroductionViolence is a salient public health issue (Hamburg, 1998). Violence at work has dramatically gained momentum in recentyears and is now a priority concern in both industrialized and developing countries.Violence at work has been identifiedas a serious problem in many countries allover the world (Saarela, 2002). Occupational violence has resulted in physical and psychological damage, and even deaths (Saarela, 2002).The lack of a clear, concise definition of work-related violence is one of the problems in both tracking and addressing violence as a workplace health and safety Results. About three-fourth of studied teachers were exposed to workplace violence.More than half of them experienced covert violence while 15.8% experienced overt violence. Actual physical violence was experienced by 7.5% of the teachers. Near 15% of respondent teachers were stalked and 4.7% were sexually harassed. The majority of the stalked and sexually harassed participant teachers were victimized by students, then by other teachers, school administrators, parents or family members,and lastly other school members. The majority of incidents occurred in classrooms and during school time. Only one fourth of the incidents of stalking and sexually harassment were reported to school administrators. Participant teachers reported negative impacts of violence on their own educational career, physical, and emotional status. Logistic regression analysis has revealed that teachers of cultural subjects and teachers with good health status were statistically significantly more exposed to covert and overt assaults. Younger teachers and non-general secondary school teacherswere also more prone to covert type of violence. Male teachers and general secondary school teachers were more prone to overt type of violence. The predictors of stalking were longer duration of work in years, ill health, and exposure to overt violence. For sexual harassment, the predictors were exposure to overt violence and nonexposure to stalking.Conclusion. A significant proportion of secondary school teachers in Ismailia city are exposed to workplace violence, more covert than overt. A smaller proportion is exposed to stalking and sexual harassment. Predictors of violence against teachers included age, gender, experience years, health status, type of school, and subject specialty.There is need for intervention and prevention strategies to provide better quality of life and education for the future of the country.
https://ejom.journals.ekb.eg/article_625_f8df0afc83261c9a09e01280be083b78.pdf
missed
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
209
216
10.21608/ejom.2007.626
626
DEMOGRAPHIC AND SOCIAL CHARACTERISTICS OF FEMALE SEX WORKERS IN EGYPT
Abdel Maksoud N.
1
El Safty A.
2
Salem M.
3
Background: An estimated 4.9 million people were newly infected with HIV around the world in 2005. The proportion of women infected by HIV worldwide has grown steadily and it is estimated that half of the people currently infected by HIV arewomen. Significantly higher rates of HIV infection have been documented among populations involved with sex work than in most other populations. Aim of the work:This study aimed at studying the social and demographic characteristics of sexworker females in Egypt as they constitute the major source of blood born infections specially HIV. These data were collected as part of a baseline study for putting a strategy to reduce the spread of HIV targeting key population groups who are at higher risk of acquiring and transmitting HIV infections. Methodology: Detailed documentationof demography and various aspects of sex work were gathered through confidential data from Ministry of justice. Personal interview was performed to fill a designed questionnaire. Results: A total number of 90 females were investigated withan age ranging from 15 to 30 years. Thirty per cent were illiterate, while 40 % were primary educated and 20 % college graduated. The motive for practicing this work was to earn money for basic needs of living. Conclusion: These data highlight that women struggling with illiteracy, lower social status, and less economic opportunities are especially vulnerable to work as sex worker as they were left with few options to
https://ejom.journals.ekb.eg/article_626_9750abcc2a1adf3fa4874217467fd60a.pdf
missed
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
217
236
10.21608/ejom.2007.627
627
ROLE OF ANTIOXIDANTS, ENVIRONMENTAL EXPOSURE TO LEAD AND CADMIUM IN SPONTANEOUS ABORTION.
Ahmed H.
1
El-Desouky A.
2
Rashed A.
3
Industrial Medicine & Occupational Disease and Departments of Forensic Medicine & Toxicology
Industrial Medicine & Occupational Disease and Departments of Forensic Medicine & Toxicology
Medical Biochemistry, Faculty of Medicine, Cairo University
Background and rationale: Pregnant women exposed to even low levels of environmental lead and cadmium may experience adverse perinatal effects. Aim of the work: The aim of the present study was to search for any relation between the environmental exposure to lead and cadmium and spontaneous abortion and, to emphasizethe truth about the antioxidants and their relation as a mechanism for such relation if present. Subjects and methods: 38 women were included in this study. They were divided into 2 groups: Group I: Included 14 normal pregnant women (control group).Group II: Included 24 women with spontaneous abortion (cases). All women were in their first trimester. The following investigations were performed for every woman: lead, cadmium and serum zinc, serum vitamin C, Serum glutathione and serum malondialdehyde levels. Results: Cases had statistically significant higher blood lead, cadmium levels and malondialdehyde level and, statistically significant lower serum zinc, vitamin C and glutathione levels than controls. Conclusion and Recommendations: The obtained results indicate that spontaneous abortion is accompanied by aprofound disruption of the prooxidant-antioxidant homeostasis towards oxidative stress. Increased free radical activity produced by environmental exposure to lead and cadmium has been implicated in the pathogenesis of spontaneous abortion. Industrial areas have been accused as environmentally polluted with both lead and cadmium.
https://ejom.journals.ekb.eg/article_627_c6d97d128acfcd33ea8ff0679e82b78e.pdf
missed
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
237
258
10.21608/ejom.2007.628
628
THE ROLE OF CD40 LIGAND IN EARLY DETECTION OF CHROMIUM-INDUCED IMMUNOTOXIC EFFECTS AMONG EXPOSED WORKERS
Gaballah F.
1
Zawilla H.
2
Rashed A.
3
Department of Occupational Medicine and Environmental Diseases,Faculty of Medicine, Cairo University
Department of Occupational Medicine and Environmental Diseases,Faculty of Medicine, Cairo University
Department of Biochemistry, Faculty of Medicine, Cairo University
Objective: the immunological effect of chromium exposure among workers in tanning industry was assessed by studying the incidence of structural chromosomal aberrations in lymphocytes. Early monitoring of immunotoxicity and possibility ofcarcinogenecity using the CD40 ligand member of the tumor necrosis superfamily of trans-membrane proteins was evaluated. Methods: levels of chromium in blood (S-Cr) and urine (U-Cr) were measured using the graphite furnace atomic absorption spectrophotometer. The CD40 Ligand (CD40L) was determined using ELISA. Whole blood was treated and chosen metaphases were recorded and scored for morphological aberrations and rearrangements.Results: the study was carried out on 30 workers exposed to chromium in chrome-tanning for 17.13 ± 8.09 years, and a matched group of 28 administrative workers. The mean serum chromium levels (S-Cr) were 4.35 ± 1.46 and 1.89 ± 1.31 μg/dl among exposed and control groups, respectively, and the difference was statistically significant, P<0.00±. The CD40L assessment revealed decreased levels among the exposed population, difference was statistically non-significant. The genotoxic changes in the form of chromosomal and chromatid gaps and breaks as well as dicen-actitricchanges were significantly higher among exposed workers, correlating significantlywith the levels of chromium in both serum and urine after correction for creatinine.A significant negative correlation was reported for the deletions with the level of CD40 ligand. The effect of age, smoking and cumulative exposure indices were dealt with.Conclusion: the use of cytogenetic monitoring of human populations exposed to chemicals has proved to be a useful tool for detecting the chemical's mutagenic effects.CD40L, which is a member of the tumor necrosis factor, may be used as an additional marker to assess the presence of chronic inflammation, an early warning indication of potentially adverse genetic and somatic effects.
https://ejom.journals.ekb.eg/article_628_389ea801639218bd64d5f67549e0c8b8.pdf
chromosomal aberrations
Ligands
chronic inflammation
Chromium
tanning industry
carcinogenesis
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
259
279
10.21608/ejom.2007.629
629
ERGONOMIC RISK FACTORS AND MUSCULOSKELETAL DISORDERS (PREVALENCE & COST) AMONG WORKERS IN A MULTINATIONAL CAR ASSEMBLY PLANT, EGYPT
Alazab M.
1
Public health and Industrial medicine Department, Faculty of medicine, Alazhar Uiversity, Cairo, Egypt
Objectives: to define the magnitude of the ergonomic stressors related to neck and trunk posture, energy expenditure and upper extremity among workers in the studied plant, to find out the incidence rate of work injuries resulted from ergonomic causes among the studied workers and to find out the prevalence rate and cost of musculoskeletaldisorders among the studied workers. Subjects & Methods: this study was conducted inside a multinational factory in Egypt for car assembly. 553 workers were included in the study. All workers were subjected to checklists to monitor thedifferent ergonomic stressors during their daily work. Environmental measures were conducted through coordination with National Institute of Occupational Safety and Health (NIOSH), Egypt. Data about distribution and cost of MSDs were obtained from the medical recording system inside the medical department of the factory.Results: noise, ultraviolet rays, vibration and carbon monoxide in body shop while heat and thinner in paint shop were above the permissible level. 21.7%, 3.2% and 27.6% of workers were standing stationary, kneeling and knee bent respectively.Trunk posture revealed that 43.1%, 11.8% and 49.2% of workers were doing forward bending, backward bending and lateral bending respectively. Neck posture revealed that 29.7%, 13.8% and 17.2% of workers were doing forward bending, backwardconsebendingand lateral bending respectively. About 11% were doing sit/stand position.Energy expenditure assessment revealed that; 12.1 of workers in their jobs need to walk more than 30m2/M while carrying weights. Upper extremity stressors revealed that 36.7% were doing repetitive work, 14.2%, 7.1% and 13.5% were gripping on objectwith slippery surface, tip of a finger used for pressing and gloves hinder the grip respectively. 11.3% and 5.1% of workers were pushing or pulling objects weight >300gm by one hand repeatedly and hold repeatedly an object which weighs more than 200gm in one hand respectively. 7.4% and 15.6% were using pinch grip and using rotating motion of the forearm respectively. 3.9% were exposed repeatedly to vibrating tools. It was found that; incidence rate of work injuries/100 workers/one year was (1.2) and the prevalence rate of MSDs was (23.7%). About 43% of the ergonomic core requirements were fully implemented inside the studied plant. It was estimated that the cost of MSDs/person/year 2006 was about 7300 L.E.(1281$). Conclusion:MSDs of neck was strongly associated with combined neck ergonomic stressors. Hand/Arm pain was strongly associated with repetitiveness and pushing forces. Lumbosacral disorders were strongly associated with combined trunk ergonomic stressors. The prevalence rate of MSDs was 23.7% and cost of MSDs/ person/ year 2006 was about 7300 L.E. (1281$).
https://ejom.journals.ekb.eg/article_629_485d57909e5f912ed45e5962e765ee2f.pdf
missed
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
288
291
10.21608/ejom.2007.630
630
HEALTH HAZARDS AMONG FIRE FIGHTERS
Helal SF
1
Labib D.
2
Industrial Medicine and Occupational Diseases department
Clinincal Pathology department, Faculty of Medicine-Cairo University
Background: Fire fighting is a physically demanding hazardous occupation. Fires are fought in a dynamic, changing, uncontrolled environment exposing workers to potentially toxic agents. The hazards of firefighting are classified as chemical, biological, physical, psychological and ergonomical. Objective: The aim of the present study was: (1) To investigate some of the health hazards among fire fighters with special emphasis on cytogenetic study and ventilatory functions. (2) To monitor the biological, psychological, reproductive and musculo-skeletal hazards. Subjects andmethodology: This study was conducted in a fire fighting station in El Omrania ElSharkia in Giza. The study was accomplished during the month of March 2007. The studied group comprised 24 workers in the fire fighting station. They were adult men aged between 18-33 years (23.20 ± 4.09), working on the basis of 12 hours/day with no day off. None of the workers used any protective equipment during working hours. They worked according to the need for help, and not all the time, bearing in mind that the worker may be exposed to frequent shifts or may be not exposed for several days.A referent group of 20 males matched for age [that ranged from 21-35 yrs., (23.40 ±4.05) ] , sex, socio-economic status and smoking habit , selected from relatives of the Kasr El Eini hospital patients, were also enrolled in our study. The following investigations were performed after taking individual consent: (A) All workers were interviewedusing a special questionnaire including occupational history; and full clinical examination was performed. (B) Ventilatory function tests were evaluated using aportable spirometer connected to a portable computer using the soft ware ZAN program,measuring FVC (Forced vital capacity), SVC (Slow vital capacity), FEV1%(Forced expiratory volume in the 1st second), FEV1/FVC %, PEF (Peak expiratoryflow) and (Mid expiratory flow 25-75%) MEF 25-75%. (C) Serological tests: a-HBV: Using enzyme linked immuo-sorbent assay (ELISA) HBsAg using BIORADMonolisa HBsAg ultra , Lot 7C0029 Monoclonal kit. b-HCV: Anti HCV using 3rdgeneration enzyme linked immuno sorbent-assay (ELISA) Innotest HCV Abs, Lot 165678. (D) Cytogenetic study Results: showed a statistically significant difference between the exposed and the control groups as regards spirometric evaluation. Ourresults revealed also a statistically significant difference between the exposed and the control groups as regards the chromosomal study, bearing in mind that the difference was in structural form not the numerical form. There was also a statistically significant difference between both groups as regards the occurrence of accidents, but there was no statistically significant difference between both groups as regards the psychological or reproductive hazards. Our research showed a statistically significant difference between the exposed and the control groups as regards HBV and HCV infections.Our results showed that there was a statistically significant correlation between the duration of exposure to toxins and hazardous agents in fire fighting and ventilatory function parameters. Our work illustrated that there was a statistically significant correlation between duration of exposure to toxins and hazardous agents in fire fighting and the appearance of gap and unbalanced re-arrangement in the romosomalstudy, but there was no statistically significant correlation as regards the rest of thechromosomal study. We emonstrated also that there was no statistically significantcorrelation between the age of the workers and the chromosomal aberrations. Recommendations:From the present study we recommend pre-employment and eriodicmedical examinations that should be performed to exclude those susceptible to lung diseases. Personal protective clothes and respiratory protective equipment should be used by fire fighters. Health education programs of workers about hazards of exposure to harmful agents and proper measures for protection is essential and this includestraining programs to raise awareness among fire fighters. Vaccination program should be applied to cover all the fire fighters specially against (HBV) . Rapid prophylactic treatment to injured workers and reporting system is mandatory. Finally follow recommended shift work pattern.
https://ejom.journals.ekb.eg/article_630_c4959b55bbdac442fe56f77208e42674.pdf
Chromosomal aberration-Fire fighting- Health hazards
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
301
314
10.21608/ejom.2007.631
631
CARCINOGENICITY OF CHROMIUM AMONG STEEL WORKERS: A COMPARATIVE CROSS SECTIONAL STUDY
Hassanein M.
1
Abbas A.
2
El-Hawary A.
3
Hammad A.
4
Saad A.
5
Departments of Forensic Medicine and Clinical Toxicology, Community, Environmental and Occupational Medicine
Departments of Forensic Medicine and Clinical Toxicology, Community, Environmental and Occupational Medicine
Departments of Forensic Medicine and Clinical Toxicology, Community, Environmental and Occupational Medicine
Faculty of Medicine - Zagazig University; Human Cytogentics,and Environmental and Occupational Medicine
Environmental and Occupational Medicine , National Research Centre, Egypt
Background: Certain chromium compounds are prominent metal carcinogens in both occupational and environmental settings. Objectives: The present study aimed to determine cytogenetic changes in the form of sister chromatid exchanges (SCEs) and predict chromium carcinogenicity in steel foundry workers; moreover, study the relationships between SCEs and tumor marker (CA 15-3) with the urinary chromium levels in the same group. Subjects and methods: The study included three groups; 20 apparently healthy male steel foundry workers, from different work sections, 20 apparently healthy male workers not exposed to chromium compounds, as a negative control group, and 10 lung cancer male patients from the National Cancer Institute, as a positive control group. All participants were interviewed using a pre-constructed questionnaire. Furthermore, they were subjected to urinary chromium level estimation,cytogentic study in the form of SCEs, and tumor marker (CA15-3) level measurement.Results: Steel workers had significantly higher levels of urinary chromium (5.5 ± 1.01 ٥g/L) compared to the other two groups (0.7 ± 0.19 and 0.8 ± 0.22 ٥g/L)(P<0.001). Also, steel workers had significantly higher SCEs and CA15-3 levels compared to the negative controls (non-exposed workers) (P<0.001), but significantlyexperimenlower than those of the positive controls (lung cancer patients) (P<0.01). Moreover in the studied steel workers, there were significant positive correlations between urinary chromium levels and both SCEs and CA15-3 levels. Conclusion: It could be concluded that, unprotected occupational exposure to chromium in steel production industry can carry the risk of developing cytogenetic changes and cancer. These effects can be predicted by estimation of SCEs and tumor marker (CA 15-3) levels. Recommendations: Periodic medical examinations and biological monitoring of steel foundry workers, along with improving working conditions are ommended.
https://ejom.journals.ekb.eg/article_631_201048aead2abcf42300e353cadd3dd8.pdf
Steel foundry workers
urinary chromium
sister chromatid exchanges
and tumor marker (CA15-3)
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
315
340
10.21608/ejom.2007.632
632
ENVIRONMENTAL CADMIUM EXPOSURE:ADDITIONAL RISK FACTOR FOR TYPE II DIABETES
Gaballah F.
1
Rashed A.
2
Department of Industrial Medicine and Occupational Diseases, Department of Biochemistry, Faculty of Medicine, Cairo University
Department of Industrial Medicine and Occupational Diseases, Department of Biochemistry, Faculty of Medicine, Cairo University
Objective: the contribution of environmental pollution to the overall risk for diabetes was assessed by evaluation to the role of inflammation and lipid peroxidation.Oxidative stress induced by accumulating cadmium in beta cells of pancreas was asuggested risk factor for type 2 diabetes. The antioxidant activities of glutathione peroxidase enzyme and sialic acid against reactive oxygen species were also investigated. Methods: levels of cadmium in blood (S-Cd) and urine (U-Cd) were measured using the graphite furnace atomic absorption spectrophotometer. Fasting glucose level (FBS), glutathione peroxidase enzyme (GSH-Px) and serum sialic acid were measured by enzymatic colorimetric assay. The glycosylated hemoglobin (HbA1c) was determined by high performance liquid chromatography.Results: the study was carried out on 26 patients diagnosed as type 2 diabetes for a mean duration of 4.66 ± 1.06 years, and a matched group of 31 non-diabetic subjects.Evaluating different life characteristics among the study population revealed an active role to rural versus urban residential areas and to current occupation in the development of diabetes in comparison to non-significant relation with feeding habits.The mean levels of serum (S-Cd) was 3.65 ± 1.17 μg/dl and 0.65 ± 0.42 μg/dl amongtype 2 diabetes and control groups, respectively, the difference was statistically highly significant, P<0.001. Similarly, highly statistically significant differences between the two groups were obtained for creatinine-corrected U-Cd, FBS and sialic acid, and sig- nificant differences for GSH-Px and HbA1c. Studying the associations between the different parameters, revealed that the main response variable was disease status and potential predictors included serum cadmium, creatinine-corrected urinary cadmium, residence and farming. Highly significant associations were detected for S-Cd and creatinine-corrected urinary Cd versus the kidney functions (urea, creatine and microalbuminuria),diabetes status (FBS and HbA1c), and the enzyme glutathione peroxidase.Similar results were obtained between S-Cd and sialic acid, which associated significantly with cadmium level in urine after correction for creatinine. The correlations studied between FBS and HbA1c versus the antioxidant GSH-Px as well as sialic acid proved highly significant with sialic acid only. No significant correlation was reported between the GSH-Px and the sialic acid. The effect of age, sex, body mass
index, duration and onset of diabetes were dealt with. Conclusion: Environmental pollution by the biotoxic cadmium metal has proved to be a risk factor contributing to the high incidence of type 2 diabetes among the general population. The acute phase reactant, sialic acid appeared to give new hopes by its scavenging role against the generated hydroxyl radicals, thus guarding against the possible development of diabetes. Additionally, estimation of salivary sialic acidmay be used as a predictive non-invasive bio-marker of oxidative stress induced by the accumulation of cadmium in beta cells of pancreas.
https://ejom.journals.ekb.eg/article_632_abe519a2914107f57ae88b314252777a.pdf
cadmium
environmental exposure
glutathione peroxidase enzyme
Type 2 Diabetes
sialic acid
HbA1c
pancreatic diseases
metallothioneins
eng
The Egyptian Society of Industrial Medicine
Egyptian Journal of Occupational Medicine
1110-1881
2357-058X
2007-07-01
31
2
341
356
10.21608/ejom.2007.633
633
STUDY OF SOME HEALTH EFFECTS IN WORKERS EXPOSED TO CHLOROFORM
Zawilla H.
1
Hassanin A.
2
Industrial Medicine and Occupational Diseases Dep., Faculty of Medicine, Cairo University
National Organization for Drug Control and Research (NODCAR)
Chloroform (also known as trichloromethane or methyltrichloride), is a colorless liquid with a pleasant, non-irritating odor. Most of chloroform found in the environment comes from industry; it is also found in waste water from sewage treatment plants and drinking water to which chlorine is added. Chloroform is used in pesticide formulation, in drugs and chemical industry and as a laboratory reagent. Chloroform toxicity can be attributed to the presence of both the parent compound and the formation of reactive metabolite (phosgene). Chloroform has obvious hepatic - nephrotoxicity and is a suspected human carcinogen. The genotoxic potential of chloroform has been investigated in anumber of studies both in vitro and in vivo.Also, the mechanism of action of chloroform had been investigated, several modes of actions were studied, of which cytotoxicity and cell replication, induction of gene mutation and DNA damage, lipid peroxidation and antioxidants depletion are the most common effects.Objectives: (1) To study and evaluate some of the health effects of chronic occupational exposure to chloroform when used as a main laboratory reagent, with special emphasis on hepatorenal, and cytogenetic effects. (2) Also, assessment of possible effect of chloroform in causing oxidative stress and lipid peroxidation. Methods: This study was carried out in the laboratory of Analgesic and Narcotic Drugs Department in the National Organization for Drug Control and Research. The study population was composed of 52 subjects; 30 workers were exposed to chloroform (by inhalation and skin contact) and 22 matched unexposed females were included as control.Every individual in the study was subjected to clinical examination and special questionnaire, investigation of liver and kidney functions (ALT, AST, ALK phosphatase,bilirubin, serum creatinine and blood urea). Serum malondialdehyde (MDA)was measured for assessment of lipid peroxidation, and chromosomal simple analysisstudy was done.Results: As regards the significant clinical manifestations, sensory disturbances,skin manifestations (redness, itching and allergic dermatitis), and cardio-vascularmanifestations (arrhythmia and syncope) were elicited in 50% of the exposed workers,and musculoskeletal manifestation were also found in the exposed group with statistically significant difference when compared to control.Liver and kidney function parameters did not show statistically significant difference between the two groups, while serum MDA was statistically significantly higher in the exposed group (P<0.05). Chromosomal aberrations were significantly higher in the exposed subjects. However, orrelations duration of work with MDA level, and with chromosomal aberrations, and MDA level with chromosomal aberrations were non-significant, Conclusion: Occupational exposure to chloroform as a main laboratory reagent, was associated with significant increase in lipid peroxidation indicated by increased level of a lipid peroxidation product, serum MDA, and was associated with increased chromosomal aberrations that did not correlate with the level of serum MDA or with duration of exposure. Hepatorenal function parameters were within normal, skin manifestation arrhythmia, and sensory manifestations are the most significant clinical effects.
https://ejom.journals.ekb.eg/article_633_3053a71f6972d329641632dff9919674.pdf
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