Using CD24/CD11b for Biomonitoring of Workers Exposed to Carcinogenic Chemicals in Metal Coating Processes

WS, El-Shafy; GH, El-Sherif; MF, MahaYacoub; AA, AbdEl-Samie

doi:10.21608/ejom.2025.378822.1369

Using CD24/CD11b for Biomonitoring of Workers Exposed to Carcinogenic Chemicals in Metal Coating Processes

Document Type : Original Article

Authors

¹ Department of Occupational and Environmental Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

² Department of Internal Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt

10.21608/ejom.2025.378822.1369

Abstract

Introduction: Surface coating processes have been developed to provide corrosion-resistance, increased durability for metallic products such as pipelines. Bisphenol A, bisphenol F, and phenolic novolac are the most widely used epoxy resins. Previous studies found that bisphenol A increased proliferation of acute myeloid leukaemia (AML) cells and led to the development and progression of lymphoma due to DNA damage. Blood levels of CD24 together with CD11b has been introduced as promising screening tests for early diagnosis of hematologic malignancies. Aim of Work: To evaluate the use of blood CD24/CD11b for early detection of hematological malignancies among workers exposed to epoxy resins containing Bisphenol A in metal coating processes. Materials and Methods: This cross-sectional study included 36 exposed workers, 36 administrative employees, and 36 patients with hematological malignancies. All groups underwent history and clinical examination, complete blood picture (CBC), CD24/CD11b blood level and urinary bisphenol A (BPA). Results: There was a high level of urinary BPA, CD24, CD11b, and CD24/Cd11b among the exposed and the hematological malignancies groups. The group of hematological malignancies had lower hematological parameters. The exposed group had significantly lower hemoglobin, MCV, MCH and MCHC. The urinary BPA showed positive correlation with the exposure duration, CD24 and CD11b. The exposure duration showed positive correlation with CD24. Conclusion: CD24 and CD11b can be used for early detection of hematological malignancies in workers exposed to epoxy resins. Recommendations: The blood levels of CD24 and CD11b are recommended as biological markers for early detection of hematological malignancies among workers exposed to BPA in epoxy resins.

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