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Egyptian Journal of Occupational Medicine
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A, F., F., H., N., A., A., R. (2007). EFFECT OF CYTOCHROME P450 1A1 (CYP1A1)POLYMORPHISM ON ASPHALT EXPOSURE - RELATED BIO-MARKERS. Egyptian Journal of Occupational Medicine, 31(1), 29-49. doi: 10.21608/ejom.2007.613
Farahat A; Helal F.; Abdel N.; Rashed A.. "EFFECT OF CYTOCHROME P450 1A1 (CYP1A1)POLYMORPHISM ON ASPHALT EXPOSURE - RELATED BIO-MARKERS". Egyptian Journal of Occupational Medicine, 31, 1, 2007, 29-49. doi: 10.21608/ejom.2007.613
A, F., F., H., N., A., A., R. (2007). 'EFFECT OF CYTOCHROME P450 1A1 (CYP1A1)POLYMORPHISM ON ASPHALT EXPOSURE - RELATED BIO-MARKERS', Egyptian Journal of Occupational Medicine, 31(1), pp. 29-49. doi: 10.21608/ejom.2007.613
A, F., F., H., N., A., A., R. EFFECT OF CYTOCHROME P450 1A1 (CYP1A1)POLYMORPHISM ON ASPHALT EXPOSURE - RELATED BIO-MARKERS. Egyptian Journal of Occupational Medicine, 2007; 31(1): 29-49. doi: 10.21608/ejom.2007.613

EFFECT OF CYTOCHROME P450 1A1 (CYP1A1)POLYMORPHISM ON ASPHALT EXPOSURE - RELATED BIO-MARKERS

Article 3, Volume 31, Issue 1, January 2007, Page 29-49  XML PDF (103.01 K)
Document Type: Study paper
DOI: 10.21608/ejom.2007.613
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Authors
Farahat A1; Helal F.1; Abdel N.1; Rashed A.2
1Department of Occupational Medicine & Industrial Diseases
2Department of Biochemistry,Faculty Of Medicine . Cairo University
Abstract
Asphalt fumes contain polycyclic aromatic compounds (PAC). There is a possibility of long-term health effects following chronic exposure by inhalation or skin contamination in asphalt road pavers. Objective: This study aimed at exploring the relationship between urinary 1-OH pyrene as a marker of internal dose of PAHs exposure and serum P53 protein as a response marker with the genetic polymorphism of CYP1A1 as a susceptibility marker among asphalt exposed workers. Methods: This work included 70 male individuals who were divided into an asphalt exposed group (n=43) and a matched control group (n=27). The exposed group was further subdivided into a group of paving and mixing (n=24) and a group of roller and vehicle drivers (n=19). Every participant was subjected to polymerase chain reaction (PCR) technique to detect the different genotypes of CYP1A1 gene and the expression of the p53 gene mutation. Besides, estimation of urinary 1-hydroxy pyrene (1-OHP) and serum level of mutant p53 protein was done as a PAHs exposure and response biomarkers, respectively. Results: CYP1A1*2A (Valine / Valine) was found to be the most prevalent CYP 1A1 genotype among both exposed and control groups. It was associated
Keywords
Asphalt-PAHs-CYP1A1- CYP1A1*2A-CYP1A1*1- CYP1A1*2CPolymorphism-P53 gene mutation- Urinary 1-OH Pyrene
Main Subjects
Occupational diseases
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