Introduction: Long-distance running race is a stressful event that can significantly affect virtually any of the physiologic systems of runners. More recently evidence has been mounting to support the long-distance running perception that athletes are susceptible to certain illness during intense training and major competition. Aim of Work: To focus on the immune function and neuroendocrine parameters response to prolonged (90 min) and intensive endurance running. Materials and Methods: Blood samples were collected from 12 male children runners (13.51 ± 1.29 years) 0h, 1hour, after the race. Complete blood count, secretion of cytokines in mitogen-activated cell culture and plasma, plasma concentration of β-endorphin, adrenocorticotropic hormone (ACTH), cortisol, and growth hormone (GH) were analyzed. Results: Significant increase in granulocyte and monocytes (MID-cell) count and lymphopenia were seen immediately after the race. Secretion of interleukin2 (IL-2) and interferon (IFN-γ) significantly declined at 0h and 1h after the running. Secretion of Tumor Necosis Factor (TNF-α) declined at 0h & remained suppressed until 1hours. Suppression in the secretion of (IL-1β) was observed at 1hour. Activated secretion of (IL-6) decreased after 1hours. Peak concentrations of ACTH, cortisol, β-endorphin, and GH were registered after the race (0 &1h). Conclusion: We co-ncluded that long-distance running race associated stress factors can alter physiologic balan-ce of cell-mediated versus humoral and anti-inflammatory versus proinflammatory cytokin-es. Results suggest that hypothalamic–pituitary–adrenocortical axis hormones played a sign-ificant role in the regulation of the observed changes. This information may be beneficial for development of new stress countermeasures to preserve wellness in subjects undergoing intensive physiological stress.
GS, E., & FA, D. (2016). IMMUNE AND NEUROENDOCRINE ALTERATIONS IN LONG-DISTANCE RUNNING RACE. Egyptian Journal of Occupational Medicine, 40(1), 145-159. doi: 10.21608/ejom.2016.837
MLA
El-Shamra GS; Darwish FA. "IMMUNE AND NEUROENDOCRINE ALTERATIONS IN LONG-DISTANCE RUNNING RACE", Egyptian Journal of Occupational Medicine, 40, 1, 2016, 145-159. doi: 10.21608/ejom.2016.837
HARVARD
GS, E., FA, D. (2016). 'IMMUNE AND NEUROENDOCRINE ALTERATIONS IN LONG-DISTANCE RUNNING RACE', Egyptian Journal of Occupational Medicine, 40(1), pp. 145-159. doi: 10.21608/ejom.2016.837
VANCOUVER
GS, E., FA, D. IMMUNE AND NEUROENDOCRINE ALTERATIONS IN LONG-DISTANCE RUNNING RACE. Egyptian Journal of Occupational Medicine, 2016; 40(1): 145-159. doi: 10.21608/ejom.2016.837
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